Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and –independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin

Background: There are 200-600 million betel quid (BQ) chewers in the world. BQ increases oral cancer risk. Matrix metalloproteinase-9 (MMP-9) is responsible for matrix degradation, cancer invasion and metastasis. Whether areca nut extract (ANE), a BQ component, stimulates MMP-9 secretion, and the re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Chang, Mei-Chi, Pan, Yu-Hwa, Wu, Hsyueh-Liang, Lu, Yi-Jie, Liao, Wan-Chuen, Yeh, Chien-Yang, Lee, Jang-Jaer, Jeng, Jiiang-Huei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2019
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932916/
https://ncbi.nlm.nih.gov/pubmed/31831717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102565
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi