Are we assuming too much with our statistical assumptions? Lessons learned from the ALTTO trial

BACKGROUND: Design, conduct, and analysis of randomized clinical trials (RCTs) with time to event end points rely on a variety of assumptions regarding event rates (hazard rates), proportionality of treatment effects (proportional hazards), and differences in intensity and type of events over time a...

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Vydáno v:Ann Oncol
Hlavní autoři: Holmes, E M, Bradbury, I, Williams, L S, Korde, L, de Azambuja, E, Fumagalli, D, Moreno-Aspitia, A, Baselga, J, Piccart-Gebhart, M, Dueck, A C, Gelber, R D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931237/
https://ncbi.nlm.nih.gov/pubmed/31240310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdz195
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