Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST) Is Not Attributed to MSH3 Loss in Stage I-III Colon cancer: An Automated, Digitalized Assessment by Immunohistochemistry of Whole Slides and Hot Spots()()

INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed to evaluate whether MSH3 loss is associated with EMAST in CRC. METHODS: A conse...

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Publicado en:Transl Oncol
Main Authors: Watson, Martin M, Lea, Dordi, Hagland, Hanne R., Søreide, Kjetil
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2019
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Original article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930943/
https://ncbi.nlm.nih.gov/pubmed/31677491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.08.009
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