Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation derivative of indirubin, has general water solubility and is well-tolerated. Previous studies have shown that meisoindigo reduces infl...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Ye, Yingze, Jin, Tong, Zhang, Xu, Zeng, Zhi, Ye, Baixin, Wang, Jinchen, Zhong, Yi, Xiong, Xiaoxing, Gu, Lijuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930809/
https://ncbi.nlm.nih.gov/pubmed/31920554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00553
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