Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics

Mutations and altered expression of deubiquitinating enzymes (DUBs) have been found associated with many human diseases including cancers. In this study, Ubiquitin specific protease 1 (USP1) expression was found significantly increased in some colorectal cancers (CRC). The elevated USP1 level was as...

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Foilsithe in:Front Oncol
Main Authors: Xu, Xin, Li, Shaoyan, Cui, Ximao, Han, Kunkun, Wang, Jun, Hou, Xiaodan, Cui, Long, He, Songbing, Xiao, Jiecheng, Yang, Yili
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930197/
https://ncbi.nlm.nih.gov/pubmed/31921663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01406
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