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Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer’s Disease

Noradrenergic locus coeruleus (LC) neuron loss is a significant feature of mild cognitive impairment and Alzheimer’s disease (AD). The LC is the primary source of norepinephrine in the forebrain, where it modulates attention and memory in vulnerable cognitive regions such as prefrontal cortex (PFC)...

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Bibliografski detalji
Izdano u:J Alzheimers Dis
Glavni autori: Kelly, Sarah C., McKay, Erin C., Beck, John S., Collier, Timothy J., Dorrance, Anne M., Counts, Scott E.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929678/
https://ncbi.nlm.nih.gov/pubmed/31177220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190090
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