Ibrutinib, but not zanubrutinib, induces platelet receptor shedding of GPIb-IX-V complex and integrin α(IIb)β(3) in mice and humans

The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib has proven to be efficacious in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) and related diseases. However, a major adverse side effect of ibrutinib is bleeding, including major hemorrhages. The bleeding associated with ibrutinib...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Dobie, Gasim, Kuriri, Fahd A., Omar, Musab M. A., Alanazi, Fehaid, Gazwani, Ali M., Tang, Chloe P. S., Sze, Daniel Man-yuen, Handunnetti, Sasanka M., Tam, Constantine, Jackson, Denise E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2019
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929381/
https://ncbi.nlm.nih.gov/pubmed/31869418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000640
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