In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism

Ataxin-2 (human gene symbol ATXN2) acts during stress responses, modulating mRNA translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance. Conversely, the progressive ATXN2 gain of function due to the fact of polyglutamine (polyQ)...

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Pubblicato in:Int J Mol Sci
Autori principali: Sen, Nesli-Ece, Arsovic, Aleksandar, Meierhofer, David, Brodesser, Susanne, Oberschmidt, Carola, Canet-Pons, Júlia, Kaya, Zeynep-Ece, Halbach, Melanie-Vanessa, Gispert, Suzana, Sandhoff, Konrad, Auburger, Georg
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928749/
https://ncbi.nlm.nih.gov/pubmed/31766565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235854
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