Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective p...

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Publicado no:Sci Rep
Main Authors: Maglione, Marta, Kochlamazashvili, Gaga, Eisenberg, Tobias, Rácz, Bence, Michael, Eva, Toppe, David, Stumpf, Alexander, Wirth, Alexander, Zeug, André, Müller, Franziska E., Moreno-Velasquez, Laura, Sammons, Rosanna P., Hofer, Sebastian J., Madeo, Frank, Maritzen, Tanja, Maier, Nikolaus, Ponimaskin, Evgeni, Schmitz, Dietmar, Haucke, Volker, Sigrist, Stephan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927957/
https://ncbi.nlm.nih.gov/pubmed/31873156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56133-3
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