Single-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells

Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)–mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. It is known that proteolytically digested Ebola virus (EBOV) GP interacts with 2 protrudin...

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Publicado en:J Infect Dis
Main Authors: Kondoh, Tatsunari, Letko, Michael, Munster, Vincent J, Manzoor, Rashid, Maruyama, Junki, Furuyama, Wakako, Miyamoto, Hiroko, Shigeno, Asako, Fujikura, Daisuke, Takadate, Yoshihiro, Yoshida, Reiko, Igarashi, Manabu, Feldmann, Heinz, Marzi, Andrea, Takada, Ayato
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Supplement Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927862/
https://ncbi.nlm.nih.gov/pubmed/30010949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy248
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