Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

Up-regulation of the persistent sodium current (I(NaP)) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of I(NaP) and KCC2, respectively, in neonatal rat lumbar moto...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Plantier, Vanessa, Sanchez-Brualla, Irene, Dingu, Nejada, Brocard, Cécile, Liabeuf, Sylvie, Gackière, Florian, Brocard, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927741/
https://ncbi.nlm.nih.gov/pubmed/31815668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51404
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