Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

Mutations in Cu/Zn superoxide dismutase (Sod1) have been reported in both familial and sporadic amyotrophic lateral sclerosis (ALS). In this study, we investigated the behavior of heteromeric combinations of wild-type (WT) and mutant Sod1 proteins A4V, L38V, G93A, and G93C in human cells. We showed...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brasil, Aline de Araújo, de Carvalho, Mariana Dias Castela, Gerhardt, Ellen, Queiroz, Daniela Dias, Pereira, Marcos Dias, Outeiro, Tiago Fleming, Eleutherio, Elis Cristina Araujo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926019/
https://ncbi.nlm.nih.gov/pubmed/31796595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902483116
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