The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages

Phthiocerol dimycocerosate (DIM) is a major virulence factor of the pathogen Mycobacterium tuberculosis (Mtb). While this lipid promotes the entry of Mtb into macrophages, which occurs via phagocytosis, its molecular mechanism of action is unknown. Here, we combined biophysical, cell biology, and mo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Augenstreich, Jacques, Haanappel, Evert, Ferré, Guillaume, Czaplicki, Georges, Jolibois, Franck, Destainville, Nicolas, Guilhot, Christophe, Milon, Alain, Astarie-Dequeker, Catherine, Chavent, Matthieu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926010/
https://ncbi.nlm.nih.gov/pubmed/31757855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910368116
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