PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors

PURPOSE: Oligodendroglioma (OD) has a relatively favorable prognosis, however, often undergoes malignant progression. We hypothesized that preclinical models of OD could facilitate identification of therapeutic targets in progressive OD. We established multiple OD xenografts to determine if PI3K/AKT...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Tateishi, Kensuke, Nakamura, Taishi, Juratli, Tareq A., Williams, Erik A., Matsushita, Yuko, Miyake, Shigeta, Nishi, Mayuko, Miller, Julie J., Tummala, Shilpa S., Fink, Alexandria L., Lelic, Nina, Koerner, Mara V. A., Miyake, Yohei, Sasame, Jo, Fujimoto, Kenji, Tanaka, Takahiro, Minamimoto, Ryogo, Matsunaga, Shigeo, Mukaihara, Shigeo, Shuto, Takashi, Taguchi, Hiroki, Udaka, Naoko, Murata, Hidetoshi, Ryo, Akihide, Yamanaka, Shoji, Curry, William T., Dias-Santagata, Dora, Yamamoto, Tetsuya, Ichimura, Koichi, Batchelor, Tracy T., Chi, Andrew S., Iafrate, A. John, Wakimoto, Hiroaki, Cahill, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924174/
https://ncbi.nlm.nih.gov/pubmed/30975663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-4144
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