Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

An amplifiable MRI probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r(1) at 1.4 T that was attributed to an ol...

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Veröffentlicht in:ACS Sens
Hauptverfasser: Rodríguez-Rodríguez, Aurora, Shuvaev, Sergey, Rotile, Nicholas, Jones, Chloe M., Probst, Clemens K., Ferreira, Diego Dos Santos, Graham-O´Regan, Katherine, Boros, Eszter, Knipe, Rachel S., Griffith, Jason W., Tager, Andrew M., Bogdanov, Alexei, Caravan, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924005/
https://ncbi.nlm.nih.gov/pubmed/31397156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssensors.9b01010
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