Multi-omics studies in cellular models of methylmalonic acidemia and propionic acidemia reveal dysregulation of serine metabolism

BACKGROUND: Methylmalonic acidemia (MMA) and propionic acidemia (PA) are related disorders of mitochondrial propionate metabolism, caused by defects in methylmalonyl-CoA mutase (MUT) and propionyl-CoA carboxylase (PCC), respectively. These biochemical defects lead to a complex cascade of downstream...

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Publicado no:Biochim Biophys Acta Mol Basis Dis
Main Authors: Anzmann, Arianna Franca, Pinto, Sneha, Busa, Veronica, Carlson, James, McRitchie, Susan, Sumner, Susan, Pandey, Akhilesh, Vernon, Hilary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923996/
https://ncbi.nlm.nih.gov/pubmed/31449969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.165538
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