Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block

Although the tricyclic antidepressant amitriptyline (ATL) is widely used in the clinic, the mechanism underlying its high therapeutic efficacy against neuropathic pain remains unclear. NMDA receptors (NMDARs) represent a target for ATL and are involved in sensitization of neuropathic pain. Here we d...

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Publicado no:Sci Rep
Main Authors: Stepanenko, Yulia D., Boikov, Sergei I., Sibarov, Dmitry A., Abushik, Polina A., Vanchakova, Nina P., Belinskaia, Daria, Shestakova, Natalia N., Antonov, Sergei M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923474/
https://ncbi.nlm.nih.gov/pubmed/31857688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56072-z
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