Long-Term Ibrutinib Therapy Reverses CD8(+) T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia

Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8(+) T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function. The mechanisms driving these features of exhaustion are uncertain but are likely to includ...

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發表在:Front Immunol
Main Authors: Parry, Helen M., Mirajkar, Nikhil, Cutmore, Natasha, Zuo, Jianmin, Long, Heather, Kwok, Marwan, Oldrieve, Ceri, Hudson, Chris, Stankovic, Tatjana, Paneesha, Shankara, Kelly, Melanie, Begum, Jusnara, McSkeane, Tina, Pratt, Guy, Moss, Paul
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921985/
https://ncbi.nlm.nih.gov/pubmed/31921116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02832
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