Mutation of the Transcriptional Regulator YtoI Rescues Listeria monocytogenes Mutants Deficient in the Essential Shared Metabolite 1,4-Dihydroxy-2-Naphthoate (DHNA)

Listeria monocytogenes, a Gram-positive, facultative intracellular pathogen, survives and replicates in the cytosol of host cells. Synthesis of 1,4-dihydroxy-2-naphthoate (DHNA), an intermediate of menaquinone biosynthesis, is essential for cytosolic survival of L. monocytogenes independent from its...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Chen, Grischa Y., Kao, Cheng-Yen, Smith, Hans B., Rust, Drew P., Powers, Zachary M., Li, Alexandria Y., Sauer, John-Demian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921671/
https://ncbi.nlm.nih.gov/pubmed/31685546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00366-19
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