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Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway

BACKGROUND: The survival of pancreatic cancer patients remains poor. However, the underlying molecular mechanism and new therapeutic target of pancreatic cancer are still needed to be found. Many studies have shown that the IGF2 mRNA-binding protein 2 (IGF2BP2) plays oncogenic roles in cancers. Howe...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Xu, Xiaodong, Yu, Yan, Zong, Ke, Lv, Pengwei, Gu, Yuantin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921559/
https://ncbi.nlm.nih.gov/pubmed/31852504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1470-y
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