Encapsulation in Polymeric Nanoparticles Enhances the Enzymatic Stability and the Permeability of the GLP-1 Analog, Liraglutide, Across a Culture Model of Intestinal Permeability

The potential of poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) to overcome the intestinal barrier that limits oral liraglutide delivery was evaluated. Liraglutide-loaded PLGA NPs were prepared by the double emulsion solvent evaporation method. In vitro release kinetics and enzymatic degrad...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Ismail, Ruba, Bocsik, Alexandra, Katona, Gábor, Gróf, Ilona, Deli, Mária A., Csóka, Ildikó
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920980/
https://ncbi.nlm.nih.gov/pubmed/31726699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110599
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