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Nanomedicine against Aβ Aggregation by β–Sheet Breaker Peptide Delivery: In Vitro Evidence

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood–brain barrier. In this work, we study the possibility of...

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書目詳細資料
發表在:Pharmaceutics
Main Authors: Pederzoli, Francesca, Ruozi, Barbara, Duskey, Jason, Hagmeyer, Simone, Sauer, Ann Katrin, Grabrucker, Stefanie, Coelho, Romina, Oddone, Natalia, Ottonelli, Ilaria, Daini, Eleonora, Zoli, Michele, Vandelli, Maria Angela, Tosi, Giovanni, Grabrucker, Andreas M.
格式: Artigo
語言:Inglês
出版: MDPI 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920811/
https://ncbi.nlm.nih.gov/pubmed/31683907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110572
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