Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

Mitotane is the most effective agent in post-operative treatment of adrenocortical carcinoma. In adults, the starting dose is 2–3 g/day and should be slightly increased to reach the therapeutic index of 14–20 mg/L. This study developed a population PK model for mitotane and to simulate recommended/h...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Pharmaceutics
Main Authors: Cazaubon, Yoann, Talineau, Yohann, Feliu, Catherine, Konecki, Céline, Russello, Jennifer, Mathieu, Olivier, Djerada, Zoubir
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920765/
https://ncbi.nlm.nih.gov/pubmed/31683663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110566
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares