Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma

Cancer cells undergo metabolic adaptation to sustain uncontrolled proliferation. Aerobic glycolysis and glutaminolysis are two of the most essential characteristics of cancer metabolic reprogramming. Hyper-activated PI3K/Akt and MAPK/ERK signaling pathways play central roles in cancer cell metabolic...

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發表在:Hepatology
Main Authors: Dimri, Manali, Humphries, Ashley, Laknaur, Archana, Elattar, Sawsan, Lee, Tae Jin, Sharma, Ashok, Kolhe, Ravindra, Satyanarayana, Ande
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920612/
https://ncbi.nlm.nih.gov/pubmed/31215069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30818
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