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Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma
Cancer cells undergo metabolic adaptation to sustain uncontrolled proliferation. Aerobic glycolysis and glutaminolysis are two of the most essential characteristics of cancer metabolic reprogramming. Hyper-activated PI3K/Akt and MAPK/ERK signaling pathways play central roles in cancer cell metabolic...
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| Publié dans: | Hepatology |
|---|---|
| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920612/ https://ncbi.nlm.nih.gov/pubmed/31215069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30818 |
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