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DOCK2 sets the threshold for entry into the virtual memory CD8(+) T cell compartment by negatively regulating tonic TCR triggering
The control of cytoskeletal dynamics by Dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficienc...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920543/ https://ncbi.nlm.nih.gov/pubmed/31740487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900440 |
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