ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

Microtubules are polymerized dimers of α- and β-tubulin that underlie a broad range of cellular activities. Acetylation of α-tubulin by the acetyltransferase ATAT1 modulates microtubule dynamics and functions in neurons. However, it remains unclear how this enzyme acetylates microtubules over long d...

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Vydáno v:Sci Adv
Hlavní autoři: Even, Aviel, Morelli, Giovanni, Broix, Loïc, Scaramuzzino, Chiara, Turchetto, Silvia, Gladwyn-Ng, Ivan, Le Bail, Romain, Shilian, Michal, Freeman, Stephen, Magiera, Maria M., Jijumon, A. S., Krusy, Nathalie, Malgrange, Brigitte, Brone, Bert, Dietrich, Paula, Dragatsis, Ioannis, Janke, Carsten, Saudou, Frédéric, Weil, Miguel, Nguyen, Laurent
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920029/
https://ncbi.nlm.nih.gov/pubmed/31897425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2705
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