Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing

OBJECTIVES: Serrated polyposis syndrome (SPS) is a complex disorder with a high risk of colorectal cancer for which the germline factors remain largely unknown. Here, we combined whole-exome sequencing (WES) and linkage studies in families with multiple members affected by SPS to identify candidate...

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Pubblicato in:Clin Transl Gastroenterol
Autori principali: Toma, Claudio, Díaz-Gay, Marcos, Soares de Lima, Yasmin, Arnau-Collell, Coral, Franch-Expósito, Sebastià, Muñoz, Jenifer, Overs, Bronwyn, Bonjoch, Laia, Carballal, Sabela, Ocaña, Teresa, Cuatrecasas, Miriam, Díaz de Bustamante, Aránzazu, Castells, Antoni, Bujanda, Luis, Cubiella, Joaquín, Balaguer, Francesc, Rodríguez-Alcalde, Daniel, Fullerton, Janice M., Castellví-Bel, Sergi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wolters Kluwer 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919450/
https://ncbi.nlm.nih.gov/pubmed/31663907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14309/ctg.0000000000000100
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