Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Doxorubicin- (DOX-) induced cardiotoxicity is associated with oxidative stress and cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status and determines cell susceptibility to apoptosis. This study is aimed at investigating the involvement of sirtuin 1- (SIRT1-) medi...

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Dades bibliogràfiques
Publicat a:Oxid Med Cell Longev
Autors principals: Wu, Yan-Zhao, Zhang, Lan, Wu, Zi-Xiao, Shan, Tong-tong, Xiong, Chen
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918936/
https://ncbi.nlm.nih.gov/pubmed/31885776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2150394
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