Topical sirolimus 0.1% for treating cutaneous microcystic lymphatic malformations in children and adults (TOPICAL): protocol for a multicenter phase 2, within-person, randomized, double-blind, vehicle-controlled clinical trial

BACKGROUND: Cutaneous microcystic lymphatic malformations (CMLMs) are rare conditions in children and adults. They present as clusters of vesicles full of lymph and blood to various extents, inducing maceration, esthetic impairment, pain, and impaired quality of life. The treatment is challenging. S...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Trials
Main Authors: Leducq, Sophie, Caille, Agnès, Barbarot, Sébastien, Bénéton, Nathalie, Bessis, Didier, Boccara, Olivia, Bursztejn, Anne-Claire, Chiaverini, Christine, Dompmartin, Anne, Droitcourt, Catherine, Gissot, Valérie, Goga, Dominique, Guibaud, Laurent, Herbreteau, Denis, Le Touze, Anne, Léauté-Labrèze, Christine, Lorette, Gérard, Mallet, Stéphanie, Martin, Ludovic, Mazereeuw-Hautier, Juliette, Phan, Alice, Plantin, Patrice, Quéré, Isabelle, Vabres, Pierre, Bourgoin, Hélène, Giraudeau, Bruno, Maruani, Annabel
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Study Protocol
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918625/
https://ncbi.nlm.nih.gov/pubmed/31847908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-3767-8
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