The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans

Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immunocompromising conditions. Current antifungals are suboptimal to treat this disease; therefore, novel targets and new therapies are needed. Previously, we have shown that chitosan is a critical component o...

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Publicat a:mBio
Autors principals: Maybruck, Brian T., Lam, Woei C., Specht, Charles A., Ilagan, Ma. Xenia G., Donlin, Maureen J., Lodge, Jennifer K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918072/
https://ncbi.nlm.nih.gov/pubmed/31848271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02264-19
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