Stretching single titin molecules from failing human hearts reveals titin’s role in blunting cardiac kinetic reserve

AIMS: Heart failure (HF) patients commonly experience symptoms primarily during elevated heart rates, as a result of physical activities or stress. A main determinant of diastolic passive tension, the elastic sarcomeric protein titin, has been shown to be associated with HF, with unresolved involvem...

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Dettagli Bibliografici
Pubblicato in:Cardiovasc Res
Autori principali: Chen, Mei-Pian, Kiduko, Salome A, Saad, Nancy S, Canan, Benjamin D, Kilic, Ahmet, Mohler, Peter J, Janssen, Paul M L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918063/
https://ncbi.nlm.nih.gov/pubmed/30778519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz043
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