Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling

AIMS: Under hypoxic conditions, nitrite ([Formula: see text]) can be reduced to nitric oxide (NO) eliciting vasorelaxation. However, nitrite also exerts vasorelaxant effects of potential therapeutic relevance under normal physiological conditions via undetermined mechanisms. We, therefore, sought to...

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Publicado en:Cardiovasc Res
Autores principales: Feelisch, Martin, Akaike, Takaaki, Griffiths, Kayleigh, Ida, Tomoaki, Prysyazhna, Oleksandra, Goodwin, Joanna J, Gollop, Nicholas D, Fernandez, Bernadette O, Minnion, Magdalena, Cortese-Krott, Miriam M, Borgognone, Alessandra, Hayes, Rosie M, Eaton, Philip, Frenneaux, Michael P, Madhani, Melanie
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Fast-Track Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918062/
https://ncbi.nlm.nih.gov/pubmed/31372656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz202
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