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Direct and Indirect Effects of FGF15 and FGF19 on Liver Fibrosis Development
Farnesoid X receptor (FXR) induces fibroblast growth factor 15 (FGF15, human ortholog FGF19) in the gut to potently inhibit bile acid (BA) synthesis in the liver. FXR activation in hepatic stellate cells (HSCs) reduces liver fibrosis. Fgf15(−/−) mice develop attenuated liver fibrosis but the underly...
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| Publicado no: | Hepatology |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6918008/ https://ncbi.nlm.nih.gov/pubmed/31206730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30810 |
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