A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2

The anti-VEGF antibody bevacizumab has shown efficacy for the treatment of neurofibromatosis type 2 (NF2). Theoretically, vascular endothelial growth factor receptors (VEGFRs)-specific cytotoxic T lymphocytes (CTLs) can kill both tumor vessel cells and tumor cells expressing VEGFRs. Here we show an...

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Udgivet i:Nat Commun
Main Authors: Tamura, Ryota, Fujioka, Masato, Morimoto, Yukina, Ohara, Kentaro, Kosugi, Kenzo, Oishi, Yumiko, Sato, Mizuto, Ueda, Ryo, Fujiwara, Hirokazu, Hikichi, Tetsuro, Noji, Shinobu, Oishi, Naoki, Ogawa, Kaoru, Kawakami, Yutaka, Ohira, Takayuki, Yoshida, Kazunari, Toda, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917794/
https://ncbi.nlm.nih.gov/pubmed/31848332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13640-1
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