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PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
The poly(ADP-ribose) polymerase, PARP1, plays a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. γH2A.X is the primary histone marker for DNA double-strand breaks and PARP1 localizes to H2A.X-enriched chromatin damage sites, but the basis for this association i...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6917767/ https://ncbi.nlm.nih.gov/pubmed/31848352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13641-0 |
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