Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial

BACKGROUND: Genital herpes simplex infection affects more than 500 million people worldwide. We have previously shown that COR-1, a therapeutic HSV-2 polynucleotide vaccine candidate, is safe and well tolerated in healthy subjects. OBJECTIVE: Here, we present a single center double-blind placebo-con...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M., Frazer, Ian H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917347/
https://ncbi.nlm.nih.gov/pubmed/31846475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226320
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