Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site (WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the disease is characterized by progressive neurological deficits. However, whether these symptoms result from direct...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Portela, Marta, Venkataramani, Varun, Fahey-Lozano, Natasha, Seco, Esther, Losada-Perez, Maria, Winkler, Frank, Casas-Tintó, Sergio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917273/
https://ncbi.nlm.nih.gov/pubmed/31846454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000545
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