Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK

INTRODUCTION: Existing HIV therapy using oral antiretrovirals (ARVs) can result in pill fatigue and sub-optimal adherence. Microneedle array patches (MAPs) offer non-invasive, blood-free and painless drug delivery, and may improve patient adherence. The objective of this study was to develop a novel...

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Veröffentlicht in:Eur J Pharm Biopharm
Hauptverfasser: Rajoli, Rajith KR, Flexner, Charles, Chiong, Justin, Owen, Andrew, Donnelly, Ryan F, Larrañeta, Eneko, Siccardi, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917207/
https://ncbi.nlm.nih.gov/pubmed/31525446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2019.09.011
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