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The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels

Manganese supports numerous neuronal functions but in excess is neurotoxic. Consequently, regulation of manganese flux at the blood–brain barrier (BBB) is critical to brain homeostasis. However, the molecular pathways supporting the transcellular trafficking of divalent manganese ions within the mic...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Steimle, Brittany L., Smith, Frances M., Kosman, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916508/
https://ncbi.nlm.nih.gov/pubmed/31699897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009371
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