GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist

Adhesion G protein–coupled receptors (aGPCRs) represent a distinct family of GPCRs that regulate several developmental and physiological processes. Most aGPCRs undergo GPCR autoproteolysis-inducing domain–mediated protein cleavage, which produces a cryptic tethered agonist (termed Stachel (stinger))...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhu, Beika, Luo, Rong, Jin, Peng, Li, Tao, Oak, Hayeon C., Giera, Stefanie, Monk, Kelly R., Lak, Parnian, Shoichet, Brian K., Piao, Xianhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916468/
https://ncbi.nlm.nih.gov/pubmed/31628191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008234
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