Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency

In contrast to conventional human pluripotent stem cells (hPSCs) that are related to post-implantation embryo stages, naive hPSCs exhibit features of pre-implantation epiblast. Naive hPSCs are established by resetting conventional hPSCs, or are derived from dissociated embryo inner cell masses. Here...

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Udgivet i:Stem Cell Reports
Main Authors: Bredenkamp, Nicholas, Yang, Jian, Clarke, James, Stirparo, Giuliano Giuseppe, von Meyenn, Ferdinand, Dietmann, Sabine, Baker, Duncan, Drummond, Rosalind, Ren, Yongming, Li, Dongwei, Wu, Chuman, Rostovskaya, Maria, Eminli-Meissner, Sarah, Smith, Austin, Guo, Ge
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915845/
https://ncbi.nlm.nih.gov/pubmed/31708477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.10.009
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