Whole-Genome Methylation Analysis of Phenotype Discordant Monozygotic Twins Reveals Novel Epigenetic Perturbation Contributing to the Pathogenesis of Adolescent Idiopathic Scoliosis

Background: Adolescent idiopathic scoliosis (AIS) is a complex disease affecting a large number of teenagers, especially in female. This study reveals novel epigenetic perturbation to the pathogenesis of AIS. Methods: A female monozygotic (MZ) twin pair discordant for AIS were examined for whole-exo...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Liu, Gang, Wang, Lianlei, Wang, Xinyu, Yan, Zihui, Yang, Xinzhuang, Lin, Mao, Liu, Sen, Zuo, Yuzhi, Niu, Yuchen, Zhao, Sen, Zhao, Yanxue, Zhang, Jianguo, Shen, Jianxiong, Wang, Yipeng, Qiu, Guixing, Wu, Zhihong, Wu, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914696/
https://ncbi.nlm.nih.gov/pubmed/31921798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00364
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