Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1–ALK-rearranged lung cancer

Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene confer sensitivity to ALK tyrosine kinase inhibitors (TKIs) and superior outcome in non-small-cell lung cancer (NSCLC). However, clinical courses vary widely, and recent studies suggest that molecular profiling of ALK(+) NSCL...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Mol Case Stud
Main Authors: Dietz, Steffen, Christopoulos, Petros, Gu, Lisa, Volckmar, Anna-Lena, Endris, Volker, Yuan, Zhao, Ogrodnik, Simon J., Zemojtel, Tomasz, Heussel, Claus-Peter, Schneider, Marc A., Meister, Michael, Muley, Thomas, Reck, Martin, Schlesner, Matthias, Thomas, Michael, Stenzinger, Albrecht, Sültmann, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Rapid Cancer Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913150/
https://ncbi.nlm.nih.gov/pubmed/31753813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a004630
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