MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection

Coxsackievirus B (CVB) is the major cause of human myocarditis and dilated cardiomyopathy. Toll-like receptor 3 (TLR3) is an intracellular sensor to detect pathogen's dsRNA. TLR3, along with TRAF6, triggers an inflammatory response through NF-κB signaling pathway. In the cells infected with CVB...

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Udgivet i:RNA
Main Authors: Fei, Yanru, Chaulagain, Anita, Wang, Tianying, Chen, Yang, Liu, Jinchang, Yi, Ming, Wang, Ying, Huang, Yike, Lin, Lexun, Chen, Sijia, Xu, Weizhen, Tong, Lei, Wu, Xiaoyu, Zhao, Dechao, Zhang, Fengmin, Zhao, Wenran, Zhong, Zhaohua
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913124/
https://ncbi.nlm.nih.gov/pubmed/31676570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.071985.119
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