Methotrexate Restores CD73 Expression on Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis Patients and May Contribute to Its Anti-Inflammatory Effect through Ado Production

Objectives: Th1.17 are highly polyfunctional, potentially harmful CD4(+) effector T cells (Teff) through IFN-γ and IL-17A coproduction. Th1.17 take part in the pathophysiology of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), in which their hyper activation results in part from defects in...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Med
Auteurs principaux: Bossennec, Marion, Rodriguez, Céline, Hubert, Margaux, Di-Roio, Anthony, Machon, Christelle, Guitton, Jérôme, Battiston-Montagne, Priscilla, Couturier, Mathilde, Marotte, Hubert, Caux, Christophe, Coury, Fabienne, Ménétrier-Caux, Christine
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912794/
https://ncbi.nlm.nih.gov/pubmed/31684171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8111859
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