Suppression of HIF2 signaling attenuates the initiation of hypoxia-induced pulmonary hypertension

Most published studies addressing the role of HIFs in hypoxia-induced PH development employ models that may not recapitulate the clinical setting, including the use of animals having pre-existing lung/vascular defects secondary to embryonic HIF ablation or activation. Further, critical questions inc...

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Publicado en:Eur Respir J
Main Authors: Hu, Cheng-Jun, Poth, Jens M., Zhang, Hui, Flockton, Amanda, Laux, Aya, Kumar, Sushil, McKeon, Brittany, Frid, Maria G., Mouradian, Gary, Li, Min, Riddle, Suzette, Pugliese, Steven C., Brown, R. Dale, Wallace, Eli M., Graham, Brian B., Stenmark, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911916/
https://ncbi.nlm.nih.gov/pubmed/31515405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.00378-2019
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