Hyperprogressive Disease in Lung Cancer with Transformation of Adenocarcinoma to Small-cell Carcinoma during Pembrolizumab Therapy

Hyperprogressive disease (HPD) is a paradoxical phenomenon involving the acceleration of tumor progression after treatment with immune checkpoint inhibitors (ICIs). A 66-year-old male smoker with advanced lung adenocarcinoma started pembrolizumab for progressive disease following first-line chemothe...

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Bibliographische Detailangaben
Veröffentlicht in:Intern Med
Hauptverfasser: Okeya, Komugi, Kawagishi, Yukio, Muranaka, Emiri, Izumida, Toshihide, Tsuji, Hiroshi, Takeda, Shinichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Internal Medicine 2019
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911749/
https://ncbi.nlm.nih.gov/pubmed/31327828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2169/internalmedicine.2892-19
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