Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments

The hypothesis of decreased nitric oxide (NO) bioavailability in sickle cell disease (SCD) proposes that multiple factors leading to decreased NO production and increased consumption contributes to vaso-occlusion, pulmonary hypertension, and pain. The anion nitrite is central to NO physiology as it...

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Detalhes bibliográficos
Publicado no:Nitric Oxide
Main Authors: Almeida, Luis E. F., Kamimura, Sayuri, de Souza Batista, Celia M., Spornick, Nicholas, Nettleton, Margaret Y., Walek, Elizabeth, Smith, Meghann L., Finkel, Julia, Darbari, Deepika, Wakim, Paul, Quezado, Zenaide M.N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911650/
https://ncbi.nlm.nih.gov/pubmed/31689491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2019.10.011
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