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Intratympanic Diltiazem-Chitosan Hydrogel as an Otoprotectant against Cisplatin-Induced Ototoxicity in a Mouse Model
HYPOTHESIS: Local administration of the calcium-channel blocker (CCB), diltiazem, via intratympanic (IT) chitosan-glycerophosphate (CGP) hydrogel will protect against cisplatin-induced ototoxicity. BACKGROUND: Cisplatin induces calcium-mediated apoptosis of cochlear outer hair cells (OHCs). Previous...
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| Publicado no: | Otol Neurotol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910999/ https://ncbi.nlm.nih.gov/pubmed/31746818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAO.0000000000002417 |
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