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Δ(9)-THC and related cannabinoids suppress substance P- induced neurokinin NK(1)-receptor-mediated vomiting via activation of cannabinoid CB(1) receptor
Δ(9)-THC suppresses cisplatin-induced vomiting through activation of cannabinoid CB(1) receptors. Cisplatin-evoked emesis is predominantly due to release of serotonin and substance P (SP) in the gut and the brainstem which subsequently stimulate their corresponding 5-HT(3)- and neurokinin NK(1)-rece...
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| Publicado no: | Eur J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910216/ https://ncbi.nlm.nih.gov/pubmed/31738934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2019.172806 |
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